In just 4 hours you can be at Johannesburg where you can get a connection to one of the Safari areas like Sabi Sands in one hour and spend a few days enjoying the Wildlife at Savanna Private Game Reserve, here you should see the BIG 5 especially the elusive Leopard. You may be lucky enough to see Wild dog and Cheetah.
While in South Africa you can always stay in Cape Town, and enjoy the city, in fact Port Louis in Mauritius is very reminiscent of The Victoria & Alfred Waterfront in Cape Town.
In less than 2 hours you can hop over to Tana and onto the Andasibe-Mantadia National park in around 4 hours where you would be advised to stay for 2 nights to see the famous Lemurs, 2-foot-long Chameleons and the massive Baobab trees that Madagascar is famous for.
Madagascar's lemurs—isolated from evolutionary changes of the world—radiated into the large island's many niches without much competition or predation. Lemurs are found in virtually all of Madagascar's ecosystems and share some of the social and behavioural characteristics of monkeys.
Today Madagascar is home to nearly 60 species and sub-species of lemur, ranging in size from the 25-gram pygmy mouse lemur to the larger Indri.
If you choose to fly with Emirates you will be going via Dubai anyway so why not stop off for a few days, its just under 7 hours between the two countries so around half way. You could explore the city of Dubai and stay at one of the hotels on the famous, Jumeriah Beach, from here you can visit the waterparks, go indoor skiing or ice skating, go up the Burj Khalifa (the worlds tallest building at 2,217ft tall) watch the Dubai Fountain display, all of this thrown together with a vast amount of shopping. Or for a different pace of lifer go into the desert and spend a few nights in the luxury that is the Al Maha Desert Resort, where you can go Dune bashing, watch a falconry display, practise archery or ride a camel.